| Thursday | 16 February 2017 | |||
| Krasnodar | 16:00 | Fenerbahce | Krasnodar Stadium | Krasnodar |
| Az | 18:00 | Lyon | AZ Stadion | Alkmaar |
| Monchengladbach | 18:00 | Fiorentina | Borussia Park | Monchengladbach |
| Rostov | 18:00 | Sparta Praha | Olimp 2 | Rostov-on-Don |
| Gent | 18:00 | Tottenham | KAA Gent Stadium | Ghent |
| Olympiacos | 18:00 | Osmanlispor | Stadio Georgios Karaiskakis | Piraeus |
| Celta | 18:00 | Shakhtar Donetsk | Balaidos | Vigo |
| Ludogorets | 18:00 | Kobenhavn | Nasionalen Stadion Vasil Levski | Sofia |
| Astra | 18:00 | Genk | Marin Anastasovici | Giurgiu |
| Paok | 20:05 | Schalke | Stadio Toumba | Salonika |
| H. Beer-Sheva | 20:05 | Besiktas | Turner Stadium | Beer Sheva |
| Villarreal | 20:05 | Roma | Estadio El Madrigal | Villarreal |
| Manchester United | 20:05 | St-Etienne | Old Trafford | Manchester |
| Anderlecht | 20:05 | Zenit | Constant Vanden Stock Stadium | Brussels |
| Legia | 20:05 | Ajax | Stadion Wojska | Warsaw |
| Athletic | 20:05 | Apoel | Estadio de San Mames | Bilbao |
| Wednesday | 22 February 2017 | |||
| Fenerbahce | 17:00 | Krasnodar | Sukru Saracoglu | Istanbul |
| St-Etienne | 17:00 | Manchester United | Stade Geoffroy Guichard | Saint-Etienne |
| Thursday | 23 February 2017 | |||
| Osmanlispor | 16:00 | Olympiacos | Osmanli Stadi | Ankara |
| Schalke | 18:00 | Paok | Arena AufSchalke | Gelsenkirchen |
| Besiktas | 18:00 | H. Beer-Sheva | Besiktas Arena | Istanbul |
| Roma | 18:00 | Villareal | Stadio Olimpico | Rome |
| Zenit | 18:00 | Anderlecht | Stadion Petrovskiy | St Petersburg |
| Ajax | 18:00 | Legia | Amsterdam ArenA | Amsterdam |
| Apoel | 18:00 | Athletic | GSP | Nicosia |
| Lyon | 20:05 | Az | Stadio de Lyon | Decines |
| Fiorentina | 20:05 | Monchengladbach | Stadio Artemio Franchi | Florence |
| Sparta Praha | 20:05 | Rostov | Generali Arena | Prague |
| Tottenham | 20:05 | Gent | Wembley Stadium | London |
| Shakhtar Donetsk | 20:05 | Celta | Arena Lviv | Lviv |
| Kobenhavn | 20:05 | Ludogorets | Parken | Copenhagen |
| Genk | 20:05 | Astra | KRC Genk Arena | Genk |
UEFA Europa League
UEFA Europa League 2016-17